MESOTHERAPY - HAIR LOSS & HAIR REGROWTH

ALOPECIA - PATRICIA GUEDES RITTES, MD
HAIR LOSS - TREATMENT WITH SCALP ROLLER TREATMENT
HAIR RESTORATION SYSTEM - Minoxidil Treatment Protocol
MESOPECIA - TREATMENT PROTOCOL
ANDROPECIA - TREATMENT PROTOCOL
KERACTIVE - PROTOCOL FOR THE TREATMENT OF HAIR LOSS
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ALOPECIA
Patrícia Guedes Rittes, MD

Androgenic alopecia is a common disorder affecting both men and women. Both androgenic alopecia and telogen effluvium can be treated with mesotherapy, with results ranging from good to excellent. During the Fourth International Mesotherapy Congress in 1985, the first paper outlining a protocol on this topic was presented by Dr. Philippe Petit.

Androgenic alopecia is defined by a chronic, diffuse, progressive hair loss. Patients have hair loss in a ratio of 2 to 1, that is, for every 2 new hair threads, one is lost.

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HAIR LOSS & HAIR REGROWTH
Phillipa McCaffery, MD

Androgenetic alopecia ( AGA ) is the commonest form of hair loss affecting both men and women. It affects around 50% of men and between 20% - 50 % of women by the age of 50.

AGA is caused by progressive, gradual shrinking of normal hair follicles that produce normal (terminal) hairs into miniturised hair follicles that produce fine (vellus) hairs. The terminal-to-vellus hair ratio, normally 2:1 gradually reduces until it is reversed.

Although AGA is considered by most doctors to be a cosmetic condition, it can have significant psychological and physical effects on those affected by it. Loss of hair allows increased ultraviolet light to reach the scalp and, in Australia, the highest incidence of malignant melanoma is on the scalps of balding men. AGA has also been linked to prostrate and cardiac conditions in older men. Women are particularly prone to suffering the adverse psychological effects of hairloss, as a thick head of hair is a highly valued aspect of feminine beauty in almost every culture.

AGA occurs most commonly in Caucasian men, followed by Asian and African American men. AGA has it’s lowest incidence in Native American and Eskimo men.

Almost all men and women with AGA begin to loose their hair prior to the age of 40 and many will commence loosing their hair by the age of 30.

AGA is distinguished from all other types of Alopecia by it’s gradual onset.

Men present with gradual thinning in the temporal areas, producing a V shaped frontal hairline. As baldness progresses, a bald patch appears on the crown of the head, which increases in size as the frontal hairline recedes. Eventually the receeding frontal hairline and the bald patch meet up, leading to loss of hair on most of the top of the head, whilst the hair around the base of the head remains intact. This pattern of hair loss is classified as Norwood/Hamilton stages 1-7.

Women usually present with diffuse thinning of hair on the crown of the head. This pattern of hair loss is classified as Ludwig stages 1-3. V shaped temporal recession does occur in women but usually to a lesser degree than in men. In general, women maintain their frontal hairline.

AGA is inherited however, the exact mechanism of inheritance has not been determined. It is also likely that systemic or external factors also play a role.

There are currently only 2 clinically proven, TGA/FDA–approved medications available for treatment of AGA - Minoxidil and Finasteride.

Minoxidil
Although the exact mechanism of action is unknown, Minoxidil appears to lengthen the duration of the anagen ( growth ) phase of hair, and it may increase the blood supply to the follicle. Used alone, regrowth is more pronounced on the crown than in the frontal scalp and is not noted for at least 4 months. Consequently, many people grow discouraged and give up using Minoxidil before it has had a chance to work.

Patients are advised to use Minoxidil in combination with a scalp roller to maximise the beneficial results of Minoxidil. New hair growth can be seen within 4-6 weeks with daily scalp rolling and a single application of Minoxidil per week, greatly improving patient compliance.

Treatment with Minoxidil and the Scalp Roller is necessary indefinitely as stopping treatment can lead to reversion to the pre-treatment balding pattern.

Finasteride
Finasteride is taken orally and is a 5 alpha-reductase type 2 inhibitor. It is not an antiandrogen. The drug can be used only in men. Finasteride has been shown to diminish the progression of ALA in males who are treated, and to stimulate hair regrowth.

Finasteride must be continued indefinitely because discontinuation results in gradual progression of the disorder.

In women with ALA, especially those with a component of hyperandrogenism, drugs that act as androgen suppressants (eg, spironolactone and oestradiol/ anti- androgen combination oral contraceptives) may be beneficial.

Surgical treatment of ALA has been performed for the past 4 decades via Hair Transplantation. The main problem is covering the bald area with sufficient donor plugs to produce a normal hair pattern. Micrografting produces a more natural appearance than the old technique of transplanting plugs. Scalp reduction has been attempted to decrease the size of the scalp to be covered by transplanted hair. However, the scars produced by the reduction technique often spread and become more noticeable with time.

Ideally, if treatment with Minoxidil and the Scalp Roller is commenced as soon as hair loss becomes apparent, the need for Surgical treatment can be prevented.


Non Surgical Hair Regrowth with the Scalp Roller - Combined with Minoxidil:

How does it work?
A Scalp Roller is an instrument consisting of a heavy duty plastic roller head covered in tiny stainless steel needles.(0.5mm to 1mm is ideal)

The Scalp Roller, specifically for the use in hair treatments, has three separate actions on the scalp. The needles are designed to penetrate the stratum corneum, the hard outer surface of the epidermal layer of the scalp. Hundreds of tiny channels are created through the stratum corneum, which facilitate the passage and absorption of Minoxidil into the dermis to maximize it’s absorption by the hair follicles.

The Scalp Roller also stimulates blood flow to the hair follicles via direct scalp massage. The third action of the Skin & Scalp Roller is to gently exfoliate excess skin cells which accumulate in the hair follicles, contributing to hair follicle malnutrition and ultimately hair follicle failure and permanent hair loss.

Does it hurt?
The needles of the Scalp Roller are long enough to assist in the penetration of Minoxidil, but will not damage the scalp in anyway. It is normal for the scalp to be a little sensitive when scalp rolling is first commenced, but most people report no problems after 1 week. We recommend using the Skin & Scalp Roller gently at first, increasing the pressure on the roller as the patient becomes accustomed to the sensation of scalp rolling.

BEFORE

AFTER

Can the Scalp Roller be used for women and as well as men?
Women can use the Scalp Roller alone or in conjunction with Minoxidil. We recommend female patients should also be assessed by their doctor for other symptoms of androgen excess.

Are there any side effects?
No side effects have been reported to date. Care must be taken to ensure the roller is cleaned propely between sessions.

Can the Scalp Roller be used for other forms of Alopecia?
Minoxidil is recommended as the treatment of choice for all forms of Alopecia. Prior to the advent of Minoxidil, treatment for alopecia consisted of a variety of assaults on the scalp with chemicals to injure the dermis in the hope of stimulating the follicles into anagen and /or local injections of hydrocortisone. Whilst the author has no direct evidence to date in this patient group, it certainly makes sense from first principles that needling the scalp in conjunction with Minoxidil would be beneficial in the other Alopecias, even if only giving patients the psychological support of “doing something “ whilst waiting for the Alopecia to spontaneously resolve.

HOW DOES SKIN NEEDLING WORK?

Skin Needling and Facial Mesotherapy is most easily performed using a Skin Roller. The Skin Roller causes multiple tiny pin point puncture wounds to the dermis.

This dermal damage induces the release of growth factors that stimulate the production of new collagen and elastin. New collagen production is the object of ALL skin resurfacing and rejuvenation treatments.

Skin Needling creates dermal damage without the removal of the healthy epidermis, which happens with other resurfacing techniques.

Because the epidermis is left intact, the healing period is rapid. The skin does not risk permanent structural damage, sun sensitivity, skin colour loss or hyper-pigmentation.

Skin Roller Pricing & Product Information
Skin Roller Order Form


HAIR RESTORATION SYSTEM (HRS) - FOR THE TREATMENT OF HAIRLOSS
MesoAge - Hair Restoration System - Treatment Protocol

HRS - A mixture of Minoxidil, Biotin, D-Panthenol, Azelaic Acid, Zinc, Pyridoxine & Gingko Biloba...

Minoxidil: Minoxidil is the only clinically proven way to stimulate hair regrowth. It is vasodilator medication that stimulates the production of fine (vellus) hairs in the scalp. It lengthens the duration of the anagen (growth) phase of hair and increases the blood supply to the follicle.

Azelaic Acid: is a hair growth stimulant that is found in some whole grains and in trace amounts in humans. Its current use in medicine, as a topical cream, is used in the treatment of acne. A research report by Stamatiadis in 1988 suggested that azelaic acid combinations of zinc and vitamin B6 was a strong type I 5-alpha reductase (5-AR) inhibitor.

Zinc: an enzyme inhibitor of 5-alpha reductase, blocking DHT production. At high concentrations, zinc could completely inhibit the enzyme activity.

Pyridoxine: is Vitamin B6, a water soluble compound it plays a vital role as the cofactor of a large number of essential enzymes in the human body. In hair loss treatment, Vitamin B6 potentiated the inhibitory effect of zinc. Hair growth stimulant.

D-Panthenol: also called vitamin B5. It is converted in the organism to the acid form. Pantethine is the bioactive form. There is energy production at the hair follicle

Biotin: vitamin H or B7, It is converted to carboxybiotin, acting as a cofactor in carboxylation and carboxyl radicals in the biosynthesis of fatty acids.

Gingko Biloba: a herb that promotes hair growth by increasing blood circulation to feed the hair follicles and preventing inflammation and bacterial infection around hair follicles.

MesoAge - Hair Restoration System contains an inhibitor or 5-alpha-reductase, lowering the concentrations of DHT in both plasma and tissue...

Email us at belinda@mesotherapyworldwide.com for protocol information or
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MESOAGE HAIR RESTORATION SYSTEM - Treatment Protocol


MESOPECIA - FOR THE TREATMENT OF HAIRLOSS
MesoDermal Hair Treatment Protocol

MESOPECIA - A mixture of Finesteride, Biotin, Pantothenic Acid, Zinc & Pyridoxine...

FINESTERIDE - It is a synthetic agent with androgenic activity. It is a specific steroidal competitive inhibitor of 5 alpha reductase lowering the concentrations of dihydrotestosterone in plasma and tissue.

PYRIDOXINE - Hair growth stimulant.

D-PANTHENOL - It is converted in the organism to the acid form. Pantethine is the bioactive form. There is energy production at the hair follicle.

BIOTIN - (vitamin for seborrhea) It is converted to carboxybiotin, acting as a cofactor in carboxylation & carboxyl radicals in the biosynthesis of fatty acids.

MesoPecia contains an inhibitor or 5-alpha-reductase, lowering the concentrations of DHT in both plasma and tissue...

Email us at belinda@mesotherapyworldwide.com for protocol information or
CLICK HERE FOR MORE DETAILS


ANDROPECIA - FOR THE TREATMENT OF NON & ANDROGENIC HAIRLOSS
MesoDermal Hair Treatment Protocol

ANDROPECIA - A mixture of Azaelic Acid, Biotin, Pantothenic Acid, Zinc & Pyridoxine...

AZELAIC ACID - is a hair growth stimulant that is found in some whole grains and in trace amounts in human bodies. It's current use in medicine as topical cream by prescription and is used in the treatment of acne.

A research report by Stamatiadis in 1988 suggested that azelaic acid combinations of zinc and vitamin B6 was a strong type I 5-alpha reductase (5-AR) inhibitor.

ZINC - an enzyme inhibitor of 5 alpha-reductase activity. At high concentrations, zinc could completely inhibit the enzyme activity.

PYRIDOXINE - a vitamin B6 a water soluble compound it plays a vital role as the cofactor of a large number of essential enzymes in the human body.In hair loss treatment,Vitamin B6 potentiated the inhibitory effect of zinc.

D-PANTHENOL
- also called vitamin B5 It is converted in the organism to the acid form. Pantethine is the bioactive form. There is energy production at the hair follicle.

BIOTIN - vitamin H or B7, It is converted to carboxybiotin, acting as a cofactor in carboxylation and carboxyl radicals in the biosynthesis of fatty acids.

Andropecia contains all natural ingredients and there are no hormonal side effects...

Abstract of Stamatiadis' 1988 study:
Br J Dermatol 1988 Nov;119(5):627-632

Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid.

Stamatiadis D, Bulteau-Portois MC, Mowszowicz I
Laboratoire de Biochimie B, Hopital Necker-Enfants-Malades, Paris, France.

The effects of zinc sulphate and azelaic acid on 5 alpha-reductase activity in human skin were studied using an in vitro assay with 1,2[3H]-testosterone as substrate. When added at concentrations of 3 or 9 mmol/l, zinc was a potent inhibitor of 5 alpha-reductase activity. At high concentrations, zinc could completely inhibit the enzyme activity. Azelaic acid was also a potent inhibitor of 5 alpha-reductase; inhibition was detectable at concentrations as low as 0.2 mmol/l and was complete at 3 mmol/l. An additive effect of the two inhibitors was observed. Vitamin B6 potentiated the inhibitory effect of zinc, but not of azelaic acid, suggesting that two different mechanisms are involved. When the three substances were added together at very low concentrations which had been shown to be ineffective alone, 90% inhibition of 5 alpha-reductase activity was obtained. If this inhibition is confirmed in vivo, zinc sulphate combined with azelaic acid could be an effective agent in the treatment of androgen related pathology of human skin.

PMID: 3207614, UI: 89087983


Email us at belinda@mesotherapyworldwide.com for protocol information or CLICK HERE FOR MORE DETAILS


KERACTIVE - FOR THE TREATMENT OF HAIRLOSS
MesoActive Hair Treatment Protocol

Dermal papilla and cycle of hair production
Hair is extremely complex, consisting morphologically of several different cells and chemical species (Fig. 1). The hair root lies below the surface of the skin enclosed within a hair follicle which is in turn entirely encased in connective tissue and acts as the hair producing unit.

The core of any hair follicle is the hair fiber, composed of three different types of epithelial cells: medullary, cortical and cuticular.

The medulla, or innermost layer, is only present in large thick hair. The Inner Root Sheath (IRS) surrounding the hair fi ber is composed of three cell types: the inner root sheath cuticle, Huxley’s layer, and Henle’s layer. This IRS is surrounded by another cellular envelope known as the Outer Root Sheath (ORS). These cells are in contact with the dermal papilla situated at the base of the hair follicle.

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Disclaimer and terms of issue: The information in this website has been compiled with all care, however the reader accepts the authors intention is not to provide any medical advice of any kind .The onus & responsibility of the application of any of the suggestions made in this website lies with the reader in consultation with a qualified medical practitioner. The practice of Mesotherapy or any medical application should be done under the strict supervision of a registered & qualified medical practitioner. Patients should be thoroughly examined prior to any treatment & closely monitored after it's commencement.